Tuesday, April 30, 2013

Big data analysis identifies prognostic RNA markers in a common form of breast cancer

Apr. 29, 2013 ? A Big-Data analysis that integrates three large sets of genomic data available through The Cancer Genome Atlas has identified 37 RNA molecules that might predict survival in patients with the most common form of breast cancer.

The study by researchers at the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James) initially analyzed messenger RNA (mRNA) and microRNA expression, DNA methylation data and clinical findings for 466 patients with invasive ductal carcinoma, the most common type of breast cancer.

The analysis identified 30 mRNAs and seven microRNAs -- short snippets of RNA -- that were consistently associated with patient outcome across 44 clinical and molecular subclasses, including early-stage tumors. The researchers then validated the prognostic signature using genome-wide expression data from 2,399 breast-cancer patients in eight independent groups and found that it performed better than other RNA signatures currently used for breast-cancer risk stratification.

"This is the first prognostic signature in breast cancer or other type of cancer that combines both mRNA and microRNA," says first author and researcher Dr. Stefano Volinia, associate professor of molecular virology, immunology and medical genetics at the OSUCCC -- James, "and we believe this concise RNA signature could prove useful for the clinical management of breast-cancer patients."

Principal investigator Dr. Carlo M. Croce, professor of molecular virology, immunology and medical genetics, and director of Human Cancer Genetics, notes that most of the genes involved in the RNA signature have not previously been linked to breast cancer and that unlike many other prognostic signatures, this one does not contain genes involved in the cell cycle or tumor grade.

"Most of these prognostic genes are newcomers, and therefore they might represent novel drug targets," says Croce, who is also the John W. Wolfe Chair in Human Cancer Genetics. "They also are novel genes with unknown function and need further study."

He noted that these genes could also be candidates for a blood test for early detection.

Key points related to the study's findings include:

  • The identified RNA signature might predict response to treatment, as well as being prognostic;
  • DNA methylation was used to confirm the association between mRNA expression and overall survival;
  • The signature includes mutations in PIK3CA and its pathway, indicating that the PIK3CA/AKT2/PTEN axis is an important and independent cofactor in prognosis;
  • The prognostic value of the integrated signature was highest in early stage I and II breast cancers, making this a potentially valuable biomarker signature in clinical practice.

Funding from the NIH/National Cancer Institute (grant CA 152758-03) and the Italian Association for Cancer Research (AIRC) supported this research.

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The above story is reprinted from materials provided by Ohio State University Medical Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. S. Volinia, C. M. Croce. Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1304977110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/q8fgK2k_NJs/130429154109.htm

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Neuroscientists use statistical model to draft fantasy teams of neurons

Apr. 29, 2013 ? This past weekend teams from the National Football League used statistics like height, weight and speed to draft the best college players, and in a few weeks, armchair enthusiasts will use similar measures to select players for their own fantasy football teams. Neuroscientists at Carnegie Mellon University are taking a similar approach to compile "dream teams" of neurons using a statistics-based method that can evaluate the fitness of individual neurons.

After assembling the teams, a computer simulation pitted the groups of neurons against one another in a playoff-style format to find out which population was the best. Researchers analyzed the winning teams to see what types of neurons made the most successful squads.

The results were published in the early online edition of the Proceedings of the National Academy of Sciences the week of April 29.

"We wanted to know what team of neurons would be most likely to perform best in response to a variety of stimuli," said Nathan Urban, the Dr. Frederick A. Schwertz Distinguished Professor of Life Sciences and head of the Department of Biological Sciences at Carnegie Mellon.

The human brain contains more than 100 billion neurons that work together in smaller groups to complete certain tasks like processing an odor, or seeing a color. Previous work by Urban's lab found that no two neurons are exactly alike and that diverse teams of neurons were better able to determine a stimulus than teams of similar neurons.

"The next step in our work was to figure out how to assemble the best possible population of neurons in order to complete a task," said Urban, who is also a member of the joint Carnegie Mellon/University of Pittsburgh Center for the Neural Basis of Cognition (CNBC).

However, using existing methods, scouting for the best team of neurons was a seemingly daunting task. It would be impossible for scientists to determine how each of the billions of neurons in the brain would individually respond to a multitude of stimuli. Urban and Shreejoy Tripathy, the article's lead author and graduate student in the CNBC's Program in Neural Computation, solved this problem using a statistical modeling approach, known as generalized linear models (GLMs), to analyze the cell-to-cell variability. Urban and Tripathy found that by applying this approach they were able to accurately reproduce the behavior of individual neurons in a computer, allowing them to gather statistics on each single cell.

Then, much like in fantasy football, the computer model used the statistics to put together thousands of teams of neurons. The teams competed against one another in a computer simulation to see which were able to most accurately recreate a stimulus delivered to the team of neurons. In the end researchers identified a small set of teams that they could study to see what characteristics made those populations successful.

They found that the winning teams of neurons were diverse but not as diverse as they would be if they were selected at random from the general population of neurons. The most successful sets contained a heterogeneous group of neurons that were flexible and able to respond well to a variety of stimuli.

"You can't have a football team made up of only linebackers. You need linebackers and tight ends, a quarterback and a kicker. But, the players can't just be random people off of the street; they all need to be good athletes. And you need to draft for positions, not just the best player available. If your best player is a quarterback -- you don't take another quarterback with your first pick," Urban said. "It's the same with neurons. To make the most effective grouping of neurons, you need a diverse bunch that also happens to be more robust and flexible than your average neuron."

Urban believes that GLMs can be used to further understand the importance of neuronal diversity. He plans to use the models to predict how alterations in the variability of neurons' responses, which can be caused by learning or disease, impact function.

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Story Source:

The above story is reprinted from materials provided by Carnegie Mellon University, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Shreejoy J. Tripathy, Krishnan Padmanabhan, Richard C. Gerkin, and Nathaniel N. Urban. Intermediate intrinsic diversity enhances neural population coding. PNAS, April 29, 2013 DOI: 10.1073/pnas.1221214110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/UpRHO-B1TAY/130429154105.htm

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Stylist Defends Ridiculous Gwyneth Paltrow Dress: It's Elegant!

Source: http://www.thehollywoodgossip.com/2013/04/stylist-defends-ridiculous-gwyneth-paltrow-dress-its-elegant/

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Monday, April 29, 2013

Army says no to more tanks, but Congress insists

WASHINGTON (AP) ? Built to dominate the enemy in combat, the Army's hulking Abrams tank is proving equally hard to beat in a budget battle.

Lawmakers from both parties have devoted nearly half a billion dollars in taxpayer money over the past two years to build improved versions of the 70-ton Abrams.

But senior Army officials have said repeatedly, "No thanks."

It's the inverse of the federal budget world these days, in which automatic spending cuts are leaving sought-after pet programs struggling or unpaid altogether. Republicans and Democrats for years have fought so bitterly that lawmaking in Washington ground to a near-halt.

Yet in the case of the Abrams tank, there's a bipartisan push to spend an extra $436 million on a weapon the experts explicitly say is not needed.

"If we had our choice, we would use that money in a different way," Gen. Ray Odierno, the Army's chief of staff, told The Associated Press this past week.

Why are the tank dollars still flowing? Politics.

Keeping the Abrams production line rolling protects businesses and good paying jobs in congressional districts where the tank's many suppliers are located.

If there's a home of the Abrams, it's politically important Ohio. The nation's only tank plant is in Lima. So it's no coincidence that the champions for more tanks are Rep. Jim Jordan and Sen. Rob Portman, two of Capitol's Hill most prominent deficit hawks, as well as Democratic Sen. Sherrod Brown. They said their support is rooted in protecting national security, not in pork-barrel politics.

"The one area where we are supposed to spend taxpayer money is in defense of the country," said Jordan, whose district in the northwest part of the state includes the tank plant.

The Abrams dilemma underscores the challenge that Defense Secretary Chuck Hagel faces as he seeks to purge programs that the military considers unnecessary or too expensive in order to ensure there's enough money for essential operations, training and equipment.

Hagel, a former Republican senator from Nebraska, faces a daunting task in persuading members of Congress to eliminate or scale back projects favored by constituents.

Federal budgets are always peppered with money for pet projects. What sets the Abrams example apart is the certainty of the Army's position.

Sean Kennedy, director of research for the nonpartisan Citizens Against Government Waste, said Congress should listen when one of the military services says no to more equipment.

"When an institution as risk averse as the Defense Department says they have enough tanks, we can probably believe them," Kennedy said.

Congressional backers of the Abrams upgrades view the vast network of companies, many of them small businesses, that manufacture the tanks' materials and parts as a critical asset that has to be preserved. The money, they say, is a modest investment that will keep important tooling and manufacturing skills from being lost if the Abrams line were to be shut down.

The Lima plant is a study in how federal dollars affect local communities, which in turn hold tight to the federal dollars. The facility is owned by the federal government but operated by the land systems division of General Dynamics, a major defense contractor that spent close to $11 million last year on lobbying, according to the nonpartisan Center for Responsive Politics.

The plant is Lima's fifth-largest employer with close to 700 employees, down from about 1,100 just a few years ago, according to Mayor David Berger. But the facility is still crucial to the local economy. "All of those jobs and their spending activity in the community and the company's spending probably have about a $100 million impact annually," Berger said.

Jordan, a House conservative leader who has pushed for deep reductions in federal spending, supported the automatic cuts known as the sequester that require $42 billion to be shaved from the Pentagon's budget by the end of September. The military also has to absorb a $487 billion reduction in defense spending over the next 10 years, as required by the Budget Control Act passed in 2011.

Still, said Jordan, it would be a big mistake to stop producing tanks.

"Look, (the plant) is in the 4th Congressional District and my job is to represent the 4th Congressional District, so I understand that," he said. "But the fact remains, if it was not in the best interests of the national defense for the United States of America, then you would not see me supporting it like we do."

The tanks that Congress is requiring the Army to buy aren't brand new. Earlier models are being outfitted with a sophisticated suite of electronics that gives the vehicles better microprocessors, color flat panel displays, a more capable communications system, and other improvements. The upgraded tanks cost about $7.5 million each, according to the Army.

Out of a fleet of nearly 2,400 tanks, roughly two-thirds are the improved versions, which the Army refers to with a moniker that befits their heft: the M1A2SEPv2, and service officials said they have plenty of them. "The Army is on record saying we do not require any additional M1A2s," Davis Welch, deputy director of the Army budget office, said this month.

The tank fleet, on average, is less than 3 years old. The Abrams is named after Gen. Creighton Abrams, one of the top tank commanders during World War II and a former Army chief of staff.

The Army's plan was to stop buying tanks until 2017, when production of a newly designed Abrams would begin. Orders for Abrams tanks from U.S. allies help fill the gap created by the loss of tanks for the Army, according to service officials, but congressional proponents of the program feared there would not be enough international business to keep the Abrams line going.

This pause in tank production for the U.S. would allow the Army to spend its money on research and development work for the new and improved model, said Ashley Givens, a spokeswoman for the Army's Ground Combat Systems office.

The first editions of the Abrams tank were fielded in the early 1980s. Over the decades, the Abrams supply chain has become embedded in communities across the country.

General Dynamics estimated in 2011 that there were more than 560 subcontractors throughout the country involved in the Abrams program and that they employed as many as 18,000 people. More than 40 of the companies are in Pennsylvania, according to Sen. Robert Casey, D-Pa., also a staunch backer of continued tank production.

A letter signed by 173 Democratic and Republican members of the House last year and sent to then-Defense Secretary Leon Panetta demonstrated the depth of bipartisan support for the Abrams program on Capitol Hill. They chided the Obama administration for neglecting the industrial base and proposing to terminate tank production in the United States for the first time since World War II.

Portman, who served as President George W. Bush's budget director before being elected to the Senate, said allowing the line to wither and close would create a financial mess.

"People can't sit around for three years on unemployment insurance and wait for the government to come back," Portman said. "That supply chain is going to be much more costly and much more inefficient to create if you mothball the plant."

Pete Keating, a General Dynamics spokesman, said the money from Congress is allowing for a stable base of production for the Army, which receives about four tanks a month. With the line open, Lima also can fill international orders, bringing more work to Lima and preserving American jobs, he said.

Current foreign customers are Saudi Arabia, which is getting about five tanks a month, and Egypt, which is getting four. Each country pays all of their own costs. That's a "success story during a period of economic pain," Keating said.

Still, far fewer tanks are coming out of the Lima plant than in years past. The drop-off has affected companies such as Verhoff Machine and Welding in Continental, Ohio, which makes seats and other parts for the Abrams. Ed Verhoff, the company's president, said his sales have dropped from $20 million to $7 million over the past two years. He's also had to lay off about 25 skilled employees and he expects to be issuing more pink slips in the future.

"When we start to lose this base of people, what are we going to do? Buy our tanks from China?" Verhoff said.

Steven Grundman, a defense expert at the Atlantic Council in Washington, said the difficulty of reviving defense industrial capabilities tends to be overstated.

"From the fairly insular world in which the defense industry operates, these capabilities seem to be unique and in many cases extraordinarily high art," said Grundman, a former deputy undersecretary of defense for industrial affairs and installations during the Clinton administration. "But in the greater scope of the economy, they tend not to be."

___

Online:

Abrams tank: http://www.army.mil/factfiles/equipment/tracked/abrams.html

__

Follow Richard Lardner on Twitter: https://twitter.com/rplardner

Source: http://news.yahoo.com/army-says-no-more-tanks-congress-insists-115422396.html

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Padres beat up Vogelsong, finish sweep of Giants

By BERNIE WILSON

AP Sports Writer

Associated Press Sports

updated 6:41 p.m. ET April 28, 2013

SAN DIEGO (AP) - Chase Headley, Nick Hundley and Alexi Amarista homered off Ryan Vogelsong and the San Diego Padres beat San Francisco 6-4 Sunday for their first three-game sweep of the Giants since May 2010.

Headley had three hits and Amarista scored three runs for the Padres, who've won four straight.

Pablo Sandoval had an RBI single among his career high-tying four hits for the defending World Series champion Giants lost their season-high fifth straight game. They've lost eight of 12 following a 9-4 start.

Buster Posey extended his hitting streak to nine games with a two-run homer to pull the Giants to 6-4 in the eighth. Sandoval was aboard after his third single. With runners on second and third and two outs, San Diego right fielder Chris Denorfia made a nice diving catch of Andres Torres' fly ball.

San Diego's Jason Marquis (2-2) bounced back from a 7-1 loss to Milwaukee on Monday night in which he allowed a season-high seven runs, including first-inning homers to Ryan Braun and Yuniesky Betancourt.

Marquis pitched out of trouble after loading the bases in both the second and third innings. He allowed two runs and six hits in 6 2-3 innings, walked four and struck out three.

Headley and Hundley each hit their second homer of the year while Amarista had his first. The Padres are the only team in the majors that doesn't have a player with at least three homers.

Headley homered to straightaway center field with two outs in the first.

After Brandon Crawford hit a sacrifice fly to tie it in the second, Hundley hit a two-run shot into the balcony on the second level of the Western Metal Supply Co. brick warehouse in the left-field corner with two outs in the second to give San Diego a 3-1 lead. Amarista was aboard on a single.

With rookie Jedd Gyorko aboard on a leadoff double, Amarista hit a two-run homer in the fourth that landed on top of the new right field fence and bounced over the Jack Daniel's Old No. 7 Deck and into the seats. It was the first time the Padres benefited from the new fence, which was moved in 11 feet in an attempt to make the spacious downtown ballyard play fairer.

Opponents have hit four homers that wouldn't have gone out last year, including Posey's shot in the eighth that ticked off the glove of leaping right fielder Chris Denorfia. It was Posey's third.

Amarista walked leading off the sixth. Hundley singled to chase Vogelsong and the runners advanced on Marquis' sac bunt. Amarista scored on Posey's passed ball to make it 6-2.

The Giants loaded the bases with one out in the second before Brandon Crawford hit a sacrifice fly. Marquis struck out Vogelsong to get out of the jam.

San Francisco loaded the bases again with one out in the third before Marquis got Hunter Pence to hit into a double play.

Vogelsong (1-2) went five-plus, allowing six runs, five earned, and eight hits, struck out six and walked three.

Huston Street pitched the ninth for his fifth save in five chances.

NOTES: San Diego swept the Giants for the first time since May 11-13, 2010, at San Francisco. Their last home sweep of the Giants was April 19-21, 2010. The Padres led the NL West for much of that season before staggering down the stretch and being eliminated from playoff contention on the last day by the Giants, who went on to win the World Series. ... Posey has nine RBIs and six extra-base hits during his hitting streak. ... The Padres travel to Chicago to open a four-game series against the Cubs on Monday. LHP Clayton Richard (0-2, 7.94) is scheduled to start against Jeff Samardzija (1-4, 3.03). ... The Giants open a series at Arizona on Monday night, with RHP Matt Cain (0-2, 6.59) scheduled to start against Ian Kennedy (1-2, 4.70).

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Zach Braff's Kickstarter Passes $2 Million Goal

By Eddie Wright Well that was easy. Zach Braff's Kickstarter campaign for his "Garden State" follow-up "I Wish I Were Here" has cruised past its goal of $2 million after less than a week. Braff took to Twitter to thank his supporters saying, "Dear Fans, I cannot believe your unbelievable support for WIWH. I wish [...]

Source: http://moviesblog.mtv.com/2013/04/29/zach-braffs-kickstarter-passes-goal/

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Are there more abortion doctors like Kermit Gosnell? And do we want to know? (Washington Post)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

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Compton mayor's race raises profile of former child star Rippy

Damian Dovarganes / AP

Rodney Allen Rippy poses for a photo outside Compton City Hall in March during his campaign for mayor. He finished 10th among 12 candidates.

By John Rogers, The Associated Press

COMPTON, Calif. -- Before he suddenly surfaced in the race for mayor of this hardscrabble Los Angeles suburb, Rodney Allen Rippy's name was likely to evoke that question inspired by that class of former child stars who didn't die young, end up in jail or a celebrity rehab series: "Whatever happened to that guy?"

Rippy was just 3 in 1972, when he became the toast of a generation as the pint-sized TV pitchman for the Jack In The Box fast-food chain. When he picked up a hamburger that looked as a big as a hubcap and tried to cram it into his mouth, America was entranced. When he finally said, "Too bigga eat!" a national catchphrase was born.

Soon the cute, chubby-cheeked youngster with the Afro as big as his head was hanging out in Hollywood with Michael Jackson. He made movie cameos and recorded a hit album called "Take Life a Little Easier."

Then the 1970s ended, and so did Rippy's career.


More than 30 years later, he resurfaced as a candidate for mayor in a city known variously over the years as the birthplace of gangsta rap, the murder capital of the country and the home of the drive-by shooting.

Although he got only 75 votes, finishing 10th among 12 candidates, his earnest but futile campaign raised the inevitable question of where he had been.

Rippy never strayed far from Hollywood, it turns out. He simply stepped away from the cameras.

When his Jack In The Box career ended about the time he was finishing high school, he went to college and earned a marketing degree.

"I wanted to continue to act, but at the time acting was a thing that unless you were really burning hot, you better have something on the back burner," he said recently over lunch at a Compton restaurant down the street from City Hall.

Seeing how the adults around him had turned a cute little kid from Long Beach into a national star, he decided marketing was the way to go.

He formed Ripped Marketing Group in 2000 and has promoted everything from smokeless cigarettes to leisure wear to country music. It gave him the idea, he says, that he could promote Compton too. He wanted to change the image of a city that, although financially troubled, has seen crime and gang violence drop precipitously in recent years.

He wasn't the first child star to remerge from anonymity to run for office. His contemporary, the late Gary Coleman, did the same when he launched his quixotic campaign for governor of California in 2003.

Unlike Coleman and many other former child stars, Rippy never got into a fistfight with an autograph seeker. He hasn't been caught in a crack house or drunkenly crashed his car.

"Don't get me wrong, I know the good, the bad, the ugly, but I have sense enough to stay away from it," he said. "My mom always said, 'Rodney, you need to understand this: It's very easy to get into trouble. It's very difficult to get out."

The Afro and the chubby cheeks are gone, but Rippy's appearance often has people scratching their heads, wondering where they've seen him before. Their reaction when they find out is sometimes like that of Saudia Pearsall's.

"THE RODNEY ALLEN RIPPY?" the waitress shouted with glee after she spotted him at a back table.

"Ahhhhh! I might vote for you just because I like you," she added, laughing. "That little Afro. 'This burger's too bigga eat!'"

A day later, she was having second thoughts, realizing she didn't know much about his campaign.

Her reaction ? delight at meeting a celebrity but wondering what the heck he's doing here ? is something Rippy says he sees often.

Rippy lost out on a marketing job once, when the person he was to work for started to believe he was being punked for a reality show: "He thought it was some kind of game, like I had some sort of hat-cam on."?

? 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Sunday, April 28, 2013

Today in History

Today is Saturday, April 27, the 117th day of 2013. There are 248 days left in the year.

Today's Highlight in History:

On April 27, 1813, the Battle of York took place in Upper Canada during the War of 1812 as a U.S. force defeated the British garrison in present-day Toronto before withdrawing.

On this date:

In 1521, Portuguese explorer Ferdinand Magellan was killed by natives in the Philippines.

In 1777, the only land battle in Connecticut during the Revolutionary War, the Battle of Ridgefield, took place, resulting in a limited British victory.

In 1805, during the First Barbary War, an American-led force of Marines and mercenaries captured the city of Derna, on the shores of Tripoli.

In 1822, the 18th president of the United States, Ulysses S. Grant, was born in Point Pleasant, Ohio.

In 1865, the steamer Sultana exploded on the Mississippi River near Memphis, Tenn., killing more than 1,400 people, mostly freed Union prisoners of war.

In 1938, King Zog I of the Albanians married Countess Geraldine Apponyi de Nagy-Apponyi.

In 1941, German forces occupied Athens during World War II.

In 1967, Expo '67 was officially opened in Montreal by Canadian Prime Minister Lester B. Pearson.

In 1973, Acting FBI Director L. Patrick Gray resigned after it was revealed that he'd destroyed files removed from the safe of Watergate conspirator E. Howard Hunt.

In 1982, the trial of John W. Hinckley Jr., who had shot four people, including President Ronald Reagan, began in Washington. (The trial ended with Hinckley's acquittal by reason of insanity.)

In 1992, the new Federal Republic of Yugoslavia was proclaimed in Belgrade by the republic of Serbia and its lone ally, Montenegro. Russia and 12 other former Soviet republics won entry into the International Monetary Fund and the World Bank. Betty Boothroyd became the first female Speaker of Britain's House of Commons.

In 2011, powerful tornadoes raked the South and Midwest; according to the National Oceanic and Atmospheric Administration, more than 120 twisters resulted in 316 deaths.

Ten years ago: The U.S. military arrested the self-anointed mayor of Baghdad, Mohammed Mohsen al-Zubaidi (moh-SEHN' ahl-zoo-BY'-dee), accusing him of exerting authority he didn't have. (He was released on May 11, 2003.) Nicanor Duarte won Paraguay's presidential election. Kevin Millwood pitched a no-hitter to lead the Philadelphia Phillies over the San Francisco Giants 1-0.

Five years ago: Afghan President Hamid Karzai (HAH'-mihd KAHR'-zeye) escaped an attempt on his life during a ceremony in Kabul marking Afghanistan's victory over Soviet occupation in the 1980s; three other people were killed in the shooting. Ashley Force, 25, became the first woman to win a national Funny Car race as she beat her father, drag racing icon John Force, in the final round of the 28th annual Summit Racing Equipment Southern Nationals in Commerce, Ga.

One year ago: President Barack Obama signed an order aimed at addressing growing complaints about fraudulent marketing and recruiting practices aimed at military families eligible for federal education aid under the GI Bill. The space shuttle Enterprise, mounted atop a jumbo jet, sailed over the New York City skyline on its final flight before becoming a museum piece aboard the USS Intrepid.

Today's Birthdays: Actress Anouk Aimee is 81. Announcer Casey Kasem is 81. Actress Judy Carne is 74. Rock musician Jim Keltner is 71. Rhythm-and-blues singer Cuba Gooding is 69. Singer Ann Peebles is 66. Rock singer Kate Pierson (The B-52's) is 65. Rhythm-and-blues singer Herbie Murrell (The Stylistics) is 64. Actor Douglas Sheehan is 64. Rock musician Ace Frehley is 62. Pop singer Sheena Easton is 54. Actor James Le Gros (groh) is 51. Rock musician Rob Squires (Big Head Todd and the Monsters) is 48. Singer Mica (MEE'-shah) Paris is 44. Actor David Lascher is 41. Actress Maura West is 41. Actress Sally Hawkins is 37. Rock musician Patrick Hallahan (My Morning Jacket) is 35. Rock singer Jim James (My Morning Jacket) is 35. Rock singer-musician Travis Meeks (Days of the New) is 34. Actress Ari Graynor is 30. Rock singer-musician Patrick Stump (Fall Out Boy) is 29. Actor William Moseley is 26. Singer Allison Iraheta is 21.

Thought for Today: "Everyone is a prisoner of his own experiences. No one can eliminate prejudices ? just recognize them." ? Edward R. Murrow, American broadcast journalist (1908-1965).

(Above Advance for Use Saturday, April 27)

Copyright 2013, The Associated Press. All rights reserved.

Source: http://news.yahoo.com/today-history-050206767.html

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AP PHOTOS: Survivors found in Bangladesh collapse

AAA??Apr. 27, 2013?12:42 PM ET
AP PHOTOS: Survivors found in Bangladesh collapse
By The Associated Press?THE ASSOCIATED PRESS STATEMENT OF NEWS VALUES AND PRINCIPLES?By The Associated Press

A survivor is carried on a stretcher into a waiting ambulance after being evacuated from a garment factory building that collapsed Wednesday in Savar, near Dhaka, Bangladesh, Saturday, April 27, 2013. Police in Bangladesh took five people into custody in connection with the collapse of a shoddily-constructed building this week, as rescue workers pulled 19 survivors out of the rubble on Saturday and vowed to continue as long as necessary to find others despite fading hopes.(AP Photo/Wong Maye-E)

A survivor is carried on a stretcher into a waiting ambulance after being evacuated from a garment factory building that collapsed Wednesday in Savar, near Dhaka, Bangladesh, Saturday, April 27, 2013. Police in Bangladesh took five people into custody in connection with the collapse of a shoddily-constructed building this week, as rescue workers pulled 19 survivors out of the rubble on Saturday and vowed to continue as long as necessary to find others despite fading hopes.(AP Photo/Wong Maye-E)

Rescue workers provide Oxygen to a survivor from the garment factory building that collapsed Wednesday in Savar, near Dhaka, Bangladesh, Saturday, April 27, 2013. Police in Bangladesh took five people into custody in connection with the collapse of a shoddily-constructed building this week, as rescue workers pulled 19 survivors out of the rubble on Saturday and vowed to continue as long as necessary to find others despite fading hopes.(AP Photo/Ismail Ferdous)

Rescue workers evacuate a survivor from the garment factory building that collapsed Wednesday, in Savar, near Dhaka, Bangladesh, Saturday, April 27, 2013. Police in Bangladesh took five people into custody in connection with the collapse of a shoddily-constructed building this week, as rescue workers pulled 19 survivors out of the rubble on Saturday and vowed to continue as long as necessary to find others despite fading hopes. (AP Photo/Ismail Ferdous)

A survivor is given oxygen as she was evacuated from a garment factory building that collapsed Wednesday in Savar, near Dhaka, Bangladesh, Saturday, April 27, 2013. Police in Bangladesh took five people into custody in connection with the collapse of a shoddily-constructed building this week, as rescue workers pulled 19 survivors out of the rubble on Saturday and vowed to continue as long as necessary to find others despite fading hopes.(AP Photo/Wong Maye-E)

A survivor, seen at bottom right, is evacuated from a garment factory building that collapsed Wednesday in Savar, near Dhaka, Bangladesh, Saturday, April 27, 2013. Police in Bangladesh took five people into custody in connection with the collapse of a shoddily-constructed building this week, as rescue workers pulled 19 survivors out of the rubble on Saturday and vowed to continue as long as necessary to find others despite fading hopes.(AP Photo/Wong Maye-E)

Working round-the-clock, rescuers have pulled more than two dozen survivors from the rubble of a Bangladesh garment factory that collapsed 4 days ago, killing some 350 people.

From within the wreckage, "We are still getting response from survivors though they are becoming weaker slowly," said Brig. Gen. Ali Ahmed Khan, the head of the fire services.

"The building is very vulnerable. Any time the floors could collapse. We are performing an impossible task, but we are glad that we are able to rescue so many survivors," he said.

The disaster is the worst ever for the country's booming and powerful garment industry, surpassing a fire five months ago that killed 112 people and brought widespread pledges to improve worker-safety standards.

Here are some images from the recovery scene.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-27-AS-Bangladesh-Survivors-Photo-Gallery/id-dfe70801c31047358d83384bf01b8f40

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Obama readies for annual correspondents' dinner

Late-night television host and comedian Conan O'Brien tours the Brady Press Briefing room of the White House in Washington, Friday, April, 26, 2013. O'Brien visited the White House ahead of his schedule hosting of the annual White House Correspondents Dinner on Saturday. (AP Photo/Pablo Martinez Monsivais)

Late-night television host and comedian Conan O'Brien tours the Brady Press Briefing room of the White House in Washington, Friday, April, 26, 2013. O'Brien visited the White House ahead of his schedule hosting of the annual White House Correspondents Dinner on Saturday. (AP Photo/Pablo Martinez Monsivais)

Late-night television host and comedian Conan O'Brien gives a 'thumbs-up' as he tours the Brady Press Briefing room of the White House in Washington, Friday, April, 26, 2013. O'Brien visited the White House ahead of his schedule hosting of the annual White House Correspondents Dinner on Saturday. (AP Photo/Pablo Martinez Monsivais)

Late-night television host and comedian Conan O'Brien tours the Brady Press Briefing room of the White House in Washington, Friday, April, 26, 2013. O'Brien visited the White House ahead of his schedule hosting of the annual White House Correspondents Dinner on Saturday. (AP Photo/Pablo Martinez Monsivais)

WASHINGTON (AP) ? The annual gathering not far from the White House brings together journalists, government officials, politicians and media personalities for what's usually an evening of light-hearted banter and celebrity gawking.

Presidents are made fun of and they poke at themselves, too.

But President Barack Obama's scheduled appearance Saturday night at the White House Correspondents' Association dinner was coming at a somber time, nearly two weeks after the deadly Boston Marathon bombing and 10 days after a devastating fertilizer plant explosion in West, Texas.

In 1995, in the aftermath of the Oklahoma City bombing, President Bill Clinton dispensed with the traditional presidential humor to remember victims and praise journalists for their coverage of the explosion.

Coincidentally, this year's dinner entertainer, comedian and late-night TV talk-show host Conan O'Brien, also headlined that 1995 gala.

Obama spent the afternoon on the golf course at Andrews Air Force Base with former U.S. Trade Representative Ron Kirk and two White House aides.

Six journalists, including Associated Press White House Correspondent Julie Pace, were to be awarded prizes for their coverage of the presidency and national issues.

The New Yorker's Ryan Lizza won the Aldo Beckman Award, which recognizes excellence in the coverage of the presidency.

Pace won the Merriman Smith Award for a print journalist for coverage on deadline.

ABC's Terry Moran was the winner of the broadcast Merriman Smith Award for deadline reporting.

Reporters Jim Morris, Chris Hamby and Ronnie Greene of the Center for Public Integrity won the Edgar A. Poe Award for coverage of issues of national significance.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-27-Obama-Correspondents/id-f1c7f6d049544bf49971564b437c0cfc

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Saturday, April 27, 2013

Military grooms new officers for war in cyberspace

AIR FORCE ACADEMY, Colo. (AP) ? The U.S. service academies are ramping up efforts to groom a new breed of cyberspace warriors to confront increasing threats to the nation's military and civilian computer networks that control everything from electrical power grids to the banking system.

Students at the Army, Navy and Air Force academies are taking more courses and participating in elaborate cyberwarfare exercises as the military educates a generation of future commanders in the theory and practice of computer warfare.

The academies have been training cadets in cyber for more than a decade. But the effort has taken on new urgency amid warnings that hostile nations or organizations might be capable of crippling attacks on critical networks.

James Clapper, director of national intelligence, called cyberattack the top threat to national security when he presented the annual Worldwide Threat Assessment to Congress this month. "Threats are more diverse, interconnected, and viral than at any time in history," his report stated. "Destruction can be invisible, latent, and progressive."

China-based hackers have long been accused of cyber intrusions, and earlier this year the cybersecurity firm Mandiant released a report with new details allegedly linking a secret Chinese military unit to years of cyberattacks against U.S. companies. This year, The New York Times, The Wall Street Journal and The Washington Post all reported breaches in their computer systems and said they suspected Chinese hackers. China denies carrying out cyberattacks.

On Tuesday, hackers compromised Associated Press Twitter accounts and sent out a false tweet. AP quickly put out word that the report was false and that its accounts had been hacked. AP's accounts were shut down until the problem was corrected.

Once viewed as an obscure and even nerdy pursuit, cyber is now seen as one of the hottest fields in warfare ? "a great career field in the future," said Ryan Zacher, a junior at the Air Force Academy outside Colorado Springs, Colo., who switched from aeronautical engineering to computer science.

Last year the U.S. Naval Academy in Annapolis, Md., began requiring freshmen to take a semester on cybersecurity, and it is adding a second required cyber course for juniors next year.

The school offered a major in cyber operations for the first time this year to the freshman class, and 33 midshipmen, or about 3 percent of the freshmen, signed up for it. Another 79 are majoring in computer engineering, information technology or computer science, bringing majors with a computer emphasis to about 10 percent of the class.

"There's a great deal of interest, much more than we could possibly, initially, entertain," said the academy's superintendent, Vice Adm. Michael Miller.

Since 2004, the Air Force Academy has offered a degree in computer science-cyberwarfare ? initially called computer science-information assurance ? that requires cadets to take courses in cryptology, information warfare and network security in addition to standard computer science. The academy is retooling a freshman computing course so that more than half its content is about cyberspace, and is looking into adding another cyber course.

"All of these cadets know that they are going to be on the front lines defending the nation in cyber," said Martin Carlisle, a computer science professor at the Air Force Academy and director of the school's Center for Cyberspace Research.

About 25 Air Force cadets will graduate this year with the computer science-cyberwarfare degree, and many will go on to advanced studies and work in their service's cyber headquarters or for U.S. Cyber Command at Fort Meade, Md., the Defense Department command responsible for defensive and offensive cyberwarfare.

Almost every Army cadet at the U.S. Military Academy at West Point, N.Y., takes two technology courses related to such topics as computer security and privacy. West Point also offers other cyber courses, and a computer security group meets weekly. One of the biggest cybersecurity challenges is keeping up with the head-spinning pace of change in the field.

"You know American history is pretty much the same" every year, said Lt. Col. David Raymond, who teaches a cybersecurity course. "In this domain, it's really tough to keep up with how this thing evolves."

In his congressional report, Clapper noted that the chance of a major attack by Russia, China or another nation with advanced cyber skills is remote outside a military conflict ? but that other nations or groups could launch less sophisticated cyberattacks in hopes of provoking the United States or in retaliation for U.S. actions or policies overseas. South Korea accused North Korea of mounting a cyberattack in March that shut down thousands of computers at banks and television broadcasters.

Gen. Keith Alexander, head of U.S. Cyber Command, told Congress in March the command is creating teams to carry out both offensive and defensive operations. A spokesman said the command is drawing cyber officers from the service academies, officer schools and Reserve Officer Training Corps programs.

Teams from the three academies compete in events such as last week's National Security Agency Cyber Defense Exercise, in which they try to keep simulated computer networks running as an NSA "aggressor team" attacks. Teams from the U.S. Coast Guard and Merchant Marine academies also took part, along with graduate students from the U.S. Naval Postgraduate School and Canada's Royal Military College.

Air Force won among undergraduate schools. The Royal Military College won among graduate schools.

That hands-on experience is invaluable, said 2nd Lt. Jordan Keefer, a 2012 Air Force Academy graduate now pursuing a master's degree in cyberoperations at the Air Force Institute of Technology.

"You can't just go out there and start hacking. That's against the law," he said. The competitions, he said, "gave me actual experience defending a network, attacking a network."

Counterterrorism expert Richard Clarke, noting that really high-level computer skills are rare, suggested the military might have to re-examine some of its recruiting standards to attract the most adept cyberwarriors.

"Hackers are the 1 percent, the elite and the creators," said Clarke, who served as White House cybersecurity adviser during the Clinton administration. "I wouldn't worry a whole heck of a lot (about whether they) can they run fast or lift weights."

Cyber's appeal was enough to get Keefer to put aside his dream of becoming a fighter pilot, a job with undeniable swagger. "It's a challenge, and for people who like a challenge, it's the only place to be," Keefer said.

___

Witte reported from Annapolis, Md. Associated Press Writer Michael Hill in Albany, N.Y., contributed to this report.

___

Follow Dan Elliott at http://twitter.com/DanElliottAP. Follow Brian Witte at http://twitter.com/APBrianWitte . Follow Michael Hill at http://twitter.com/MichaelTHill

Source: http://news.yahoo.com/military-grooms-officers-war-cyberspace-083354456.html

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Friday, April 26, 2013

Joe and Tina Simpson: Divorced!

Source: http://www.thehollywoodgossip.com/2013/04/joe-and-tina-simpson-divorced/

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Dozens rescued but Bangladesh building toll soars towards 300

By Serajul Quadir and Ruma Paul

DHAKA (Reuters) - The search for survivors from Bangladesh's worst industrial accident stretched into a third day on Friday, with the death toll rising to 273 after the collapse of a building housing factories that made low-cost garments for Western brands.

Almost miraculously, 41 people trapped inside the rubble of the eight-storey building were rescued alive late on Thursday, government minister Jahangir Kabir Nanak said, about 40 hours after the disaster on the outskirts of Dhaka.

Nanak said they had been working on the fourth floor of the Rana Plaza building and had all been found trapped in one room. Few other details were available.

Around 2,000 people have been rescued over the past two days, at least half of them injured, but as many as 1,000 people remain unaccounted for.

An industry official has said 3,122 people, mainly female garment workers, were inside the building despite warnings that it was structurally unsafe.

Rescuers from Bangladesh's army, navy and air force, as well as police and fire services, pored over huge piles of rubble and twisted metal in the search for survivors, using their bare hands as well as mechanical equipment.

"We are not sure how many people are still trapped under the rubble," said Dhaka District police chief Habibur Rahman, who updated the death toll early on Friday to 273. "Priority has been given to save people who are still alive," he said.

Wednesday's disaster refocused attention on Western high-street brands that use Bangladesh as a source of low-cost goods.

North American and European chains, including British retailer Primark and Canada's Loblaw, said they were supplied by factories in the Rana Plaza building, which is in the commercial suburb of Savar, about 30 km (20 miles) from the capital.

TRAPPED WORKERS CALL FOR HELP

Savar residents and rescuers dropped bottled water and food on Thursday night to people who called out from between floors.

Relatives identified their dead among dozens of corpses wrapped in cloth on the veranda of a nearby school.

Police said the owner of the building, Mohammed Sohel Rana, a local politician from the ruling Awami League, was told of dangerous cracks on Tuesday.

While a bank in the building closed on Wednesday because of the warnings, the five clothing companies told their workers there was no danger, industry officials said. Rana is now on the run, according to police.

"We asked the garment owners to keep it closed," said Bangladesh Garment Manufacturers and Exporters Association (BGMEA) President Mohammad Atiqul Islam.

Despite the overnight rescue of 41 people, officials conceded the chances of finding more alive were growing slimmer.

"We can't be certain of getting them all out alive. We are losing a bit of hope," fire brigade rescue worker Mizanur Rahman said earlier on Thursday.

Special prayers will be offered at mosques, temples and pagodas across Bangladesh on Friday for the dead, injured and missing. The government declared a national day of mourning and flags were flown at half mast at all official buildings.

Anger over the working conditions of Bangladesh's 3.6 million garment workers, the overwhelming majority of them women, has grown steadily since the building collapse.

More than 1,000 textile workers besieged the BGMEA on Thursday, pelting it with stones and clashing with riot police. The workers demanded all garment factories be shut and the owners harshly punished for accidents.

Bangladesh is the world's second-largest apparel exporter, with the bulk of exports - 60 percent - going to Europe. The United States takes 23 percent and Canada takes 5 percent.

Primark, a unit of Associated British Foods, has confirmed one of its suppliers occupied the second floor of the building. Danish retailer PWT Group, which owns the Texman brand, said it had been using a factory in the building for seven years.

Canada's Loblaw, a unit of food processing and distribution firm George Weston Ltd, said one factory made a small number items for its "Joe Fresh" label.

Primark, Loblaw and PWT operate under codes of conduct aimed at ensuring products are made in good working conditions.

Documents including order sheets and cutting plans obtained by Reuters appeared to show that other major brands such as Benetton had used suppliers in the building in the past year.

A Benetton spokesman said none of the factories were suppliers to the company. Spain's Mango said it had an unfulfilled sample order at the plaza with Phantom Apparel.

(Additional reporting by Anis Ahmed in Dhaka, John Chalmers in New Delhi, Jessica Wohl and Nivedita Bhattacharjee in Chicago, Solarina Ho in Toronto, Robert Hertz in Madrid and Mette Kronholm Fraende in Copenhagen; Writing by Paul Tait; Editing by Alex Richardson)

Source: http://news.yahoo.com/dozens-rescued-hundreds-missing-bangladesh-toll-tops-270-055126500--sector.html

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Survey: Americans felt more secure in jobs in 2012

(AP) ? Confidence in the U.S. job market has rebounded to roughly a normal level from its record low after the Great Recession, a trend that could help boost the economy.

Americans increasingly feel they could find a new job if necessary, according to the results of the 2012 General Social Survey, a long-standing poll of public opinion. And fear of being laid off dropped last year from its 2010 peak to roughly its average for the 35 years the question has been asked.

The percentage of Americans who said it would be somewhat or very easy to find a job if they lost theirs rose to 54 percent last year from 46 percent in 2010. The 2010 figure was the lowest since 1983, when the United States was also emerging from a deep recession. On average in the survey's history, about 58 percent of respondents have said it would be very or somewhat easy to find a job.

As layoffs have declined, fewer Americans fear losing their job. Last year, 11 percent of adults thought it was somewhat or very likely that they'd lose theirs. That was down from a record-high 16 percent in 2010. And it matches the 11 percent average the survey has found since it began asking the question.

Americans may be feeling even more secure now than when the survey was taken last year. The number of layoffs fell in January to the lowest level in the 12 years the government has tracked the data. Fewer people are seeking unemployment benefits.

And employers have stepped up hiring, though the job gains slowed in March. Employers added nearly 2.2 million jobs in 2012, an average of about 180,000 a month. That's enough to slowly lower the unemployment rate.

Even though the rate remains high at 7.6 percent, greater confidence among those who have a job could encourage more consumer spending and boost economic growth.

"If you're not afraid of being laid off, you're going to spend more of your money," said Drew Matus, an economist at UBS.

The General Social Survey has been conducted roughly every two years since 1972. The survey is a project of the independent research organization NORC at the University of Chicago, with primary funding from the National Science Foundation.

From mid-March through September last year, 1,975 adults were asked about their financial situation and their feelings about the job market. The survey's margin of error was plus or minus 2.2 percentage points. The results were only recently made available.

The survey found that confidence in the economy varied by education. Those with college degrees felt more job security than those with less education. And since the recession ended in June 2009, Americans with a college education have reported greater improvement in confidence than have those with high school degrees or less.

Only 6 percent of college-educated Americans said in 2012 that it was somewhat or very likely that they'd lose their job. That was down from 10 percent in 2010.

Those with high school degrees were also more confident in 2012: Twelve percent of this group feared losing their job, down from 19 percent two years earlier.

But Americans with less than a high school degree reported little change: 26 percent felt it was somewhat or very likely they would be laid off in 2012, about on par with the 29 percent who felt so in 2010.

On whether it would be somewhat or very easy to find another job, 59 percent of those with college degrees said so, up from 52 percent in 2010. Among high school graduates, that figure rose to 53 percent last year from 43 percent in 2010.

Those without a high school degree still lack confidence: Only 40 percent said it would be somewhat or very easy to find new work, essentially unchanged from the 41 percent who said so in 2010.

Among the survey's other findings:

? Fewer Americans say their financial situation has worsened in the past few years, though the proportion remains high. A record 37 percent of Americans in 2010 said their finances had deteriorated. In 2012, that figure fell to 30 percent, still the second-highest on record.

? More Americans define themselves as in the "lower class" than at any time since 1972. A record 8 percent classified themselves as lower class in 2012, the same as in 2010. That compares with the record low of 4 percent in 1985.

? The proportion of Americans who expect their children to be somewhat or much worse off financially than they are was 20 percent in 2012, compared with 18 percent in 2010. The figure is slightly below the record level of 22 percent in 1996.

___

Follow Chris Rugaber on Twitter at https://Twitter.com/ChrisRugaber

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-25-Poll-Job%20Security/id-280306bff3b44291830a59fbfb5fdc91

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How gut bacteria increase heart disease risk - Mother Nature Network

Gut bacteria may play a role in the development of heart disease, a new study suggests.

?

The results show, when gut bacteria feed on certain foods, such as eggs and beef, they produce a compound that may in turn increase heart disease risk, the researchers said.

?

Participants in the study with high levels of the compound, called trimethylamine-N-oxide (TMAO), in their blood were 2.5 times more likely to have a heart attack, stroke or to die over a three-year period compared with those with low levels of the compound. Even among people with no traditional risk factors for heart disease, high levels of TMAO were linked with an increased risk of these cardiovascular events.

?

The findings suggest that blood levels of TMAO could serve as a marker for predicting heart disease risk, although future studies are needed to confirm this, said study researcher Dr. Stanley Hazen, a cardiologist at the Cleveland Clinic.

?

If, in the future, researchers could develop a drug that blocks the production of TMAO, this could be a "whole new pathway" to tackle heart disease, Hazen said.

?

Previous studies had found a link between high levels of TMAO and a history of heart disease. It's thought that bacteria convert the nutrient lecithin to TMAO.

?

In the new study, the researchers took blood samples from 40 adults before and after they ate two hard- boiled eggs, a common source of lecithin. After eating the eggs, their blood levels of TMAO were elevated. But if participants took antibiotics before eating the eggs, their TMAO levels were suppressed, the researchers said.

?

In a second study, the researchers followed about 4,000 people who were being evaluated for a heart condition. (For instance, about three-quarters had high blood pressure, and 42 percent had had a prior heart attack.)

?

Participants who had a heart attack, stroke or died during the study period had higher average TMAO levels than those who didn't experience a cardiovascular event. People with high TMAO levels and no cardiovascular risk factors were 1.8 times more likely to experience a cardiovascular event than those with low levels.

?

"This is going to be a landmark observation," said Dr. Scott Wright, a cardiologist at Mayo Clinic in Rochester, Minn., who was not involved in the study. If the findings are confirmed by future studies, it may result in a shift in dietary recommendations away from foods that may cause gut bacteria to produce TMAO.

?

The findings also provide an explanation for why some people are particularly susceptible to heart disease while others are not, said Dr. Sanjay Rajagopalan, a cardiologist at Ohio State University Wexner Medical Center. In additional to genetic and environmental factors, components of our "internal environment," such as gut microbes, may play a role in this risk, he said.

?

However, the new study cannot prove that high TMAO levels cause cardiovascular disease, and future studies are needed to examine the effect of lowering TMAO levels, Rajagopalan said.

?

Wright recommended people eat mainly lean meat, such as chicken and turkey, and limit consumption of beef to one or two times a week.

?

Earlier this month, the same group of researchers published a study that found a link between consumption of carnitine, which is found in red meat, and a risk of heart disease. Carnitine is also converted by bacteria to TMAO.

?

The new study is published in the April 25 issue of the New England Journal of Medicine.

?

Pass it on: When gut bacteria feed on certain foods, they produce a compound that may increase the risk of heart disease.

?

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Related on MyHealthNewsDaily and MNN:

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This story was originally written for MyHealthNewsDaily and is republished with permission here. Copyright 2013 MyHealthNewsDaily, a TechMediaNetwork company.

Source: http://www.mnn.com/health/fitness-well-being/stories/how-gut-bacteria-increase-heart-disease-risk

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Thursday, April 25, 2013

Health insurer WellPoint's 1Q profit rises 3 pct

INDIANAPOLIS (AP) ? WellPoint Inc.'s first-quarter earnings rose about 3 percent to trump analysts' expectations, as the nation's second largest health insurer saw a revenue gain from an acquisition. It also raised its 2013 net income forecast.

Shares of the Indianapolis company rose more than 2 percent Wednesday before markets opened.

The Blue Cross Blue Shield insurer closed its $4.46 billion acquisition of Medicaid coverage provider Amerigroup Corp. late last year, and the acquisition added more than 2 million members to its enrollment in the first quarter. That helped boost the insurer's total membership more than 6 percent in the first quarter to 35.8 million people, a total that trails only UnitedHealth Group Inc.

Medicaid is the state-federal program that provides health coverage for the needy and disabled people, and it represents a growth opportunity for health insurers. States are starting to move residents who qualify for both Medicaid and Medicare, which is a federally-funded program for people over age 65 and the disabled, into managed care programs that improve their care and cut wasteful spending.

WellPoint officials have said the opportunity these "dual eligible" patients offer was a driving force behind the deal.

Many of these patients have chronic or expensive medical conditions, so the additional membership comes with high costs that can balance the extra revenue. WellPoint's benefit expense, or the total it paid in claims, climbed nearly 17 percent to $13.75 billion in the quarter.

Overall, the insurer said Wednesday it earned $885.2 million, or $2.89 per share, in the three months that ended March 31. That's up from $856.5 million, or $2.53 per share, a year ago, when the company had more shares outstanding.

Adjusted earnings totaled $2.94 per share. Analysts forecast earnings of $2.38 per share, according to FactSet.

Operating revenue jumped nearly 16 percent to $17.55 billion. Analysts expected higher revenue of $17.86 billion.

WellPoint now expects 2013 earnings of at least $7.80 per share, up from the $7.60 per share it forecast in January.

Analysts expect, on average, earnings of $7.82 per share.

WellPoint runs Blue Cross Blue Shield plans in 14 states, including California, New York and Ohio. Its stock fell 8 percent last year, as earnings slipped and costs climbed. Former CEO Angela Braly resigned last August after the insurer cut its 2012 forecast and as investor frustration started to surface over the company's performance.

The company then beat analyst expectations in the year's last two quarters, as earnings rose.

BMO Capital Markets analyst Jennifer Lynch said in research note she thinks the company is making progress with its turnaround, given that it beat expectations in the first quarter and raised its annual forecast.

WellPoint named veteran hospital executive Joseph Swedish as its next CEO in February, and he started with the insurer last month. The company's share price has climbed nearly 14 percent so far this year as of Tuesday's close.

The shares gained an additional $1.67, or 2.4 percent, to $71 about 30 minutes before the market opening.

Source: http://news.yahoo.com/health-insurer-wellpoints-1q-profit-rises-3-pct-103538832--finance.html

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Quick display comparison: Samsung Galaxy S4 versus the competition

Galaxy S4

How does Samsung's 1080p HD SuperAMOLED match up against last year's offerings and the latest LCD panels?

A pet technology of Korean giant Samsung, AMOLED displays have adorned every one of its flagship Android smartphones, going back all the way to the original Galaxy S. This year's Galaxy S4 ships with the sharpest AMOLED display yet, a Full HD SuperAMOLED display running packing 1920x1080 pixels at 440 pixels per inch. It's the first 1080p smartphone from Samsung, and so during the course of our review we decided to pit the S4's Full HD SuperAMOLED against a selection of competitors -- the iPhone 5, Nexus 4 and HTC One -- as well as last year's Galaxy S3.

We've got comparison photos -- and a general overview of where the S4 sits on our grand imaginary league table of smartphone displays -- all after the break.

More: Samsung Galaxy S4 review

read more

    

Source: http://feedproxy.google.com/~r/androidcentral/~3/RWV6aFB4J-c/story01.htm

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Rhode Island could become 10th state to allow same-sex marriage

Maira Garcia (R) and Maria Vargas wait on line to get married at the Brooklyn City Clerk's office on July 24, 2011.??

New England's gay marriage hold-out may soon join the rest of the region in allowing same-sex unions.

Rhode Island senators are expected to vote on a measure as early as Wednesday, making the state the tenth in the nation to allow same-sex marriage. A similar bill has already passed the House.

Interestingly, every single Republican senator in the state has pledged his or her support for gay marriage, making the five members the first legislative caucus of either party to unanimously sign on to same-sex marriage in any state. Democrats have traditionally led the charge for legalizing gay marriage in other states.

The state is the last in New England to bar same-sex marriage.

The New York Times notes that same sex marriage could also pass this year in Delaware, Illinois and Minnesota, where lawmakers are actively considering bills.

The Supreme Court is expected to decide in June whether the federal government must recognize same-sex marriages for tax and other legal purposes, or whether it can continue to ignore them under the Defense of Marriage Act.

Source: http://news.yahoo.com/blogs/ticket/rhode-island-could-become-10th-state-allow-same-134809048--election.html

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